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肌内素通过激活AMPK/PGC1α通路,在雄性小鼠中保护骨肌肉功能障碍

Yuta Ozaki¹, Koji Ohashi², Naoya Otaka¹

¹Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Nature communications

|August 4, 2023

概括

肌肉内素是一种心脏保护性肌肉激素,可以对抗骨肌肉缩. 补充或激活肌内素可以通过增强线粒体功能和激活AMPK/PGC1α通路来改善肌肉功能障碍.

科学领域:

肌肉生理学和衰老研究.
肌肉缩的分子机制.
肌动因的治疗潜力肌动因的治疗潜力

背景情况:

维持骨肌肉质量和功能对于健康的衰老至关重要.
肌肉蛋白被认为是一种心脏保护性肌肉蛋白.
骨肌肉缩是衰老和疾病的一个重要问题.

研究的目的:

为了研究肌肉菌素在骨肌肉缩中的作用.
探索肌肉功能障碍中肌肉菌素的治疗潜力.
阐明肌肉上肌肉菌素的作用背后的分子机制.

主要方法:

利用与年龄相关的男性小鼠模型,肌肉缩诱导的肌肉缩和甲诱导的肌肉缩.
在肌肉组织中评估线粒体功能和基因表达 (包括PGC1α).
研究了肌肉菌素补充剂的影响及其对AMPK信号传递的影响.
检查了myonectin在老化加速和杜申肌肉衰竭小鼠模型中的疗效.

主要成果:

肌内素缺乏加剧了骨肌肉缩和线粒体功能障碍.
肌肉蛋白补充剂通过AMPK激活减弱了通过缩诱导的缩.
肌内因AMPK/PGC1α信号传递而逆转了培养肌管中德克萨米他诱导的缩.
在加速衰老和肌肉发育不良的模型中,myonectin治疗抑制了肌肉缩.

结论:

肌内素通过AMPK/PGC1α-依赖机制改善骨肌肉功能障碍.
肌肉菌素对各种形式的肌肉缩具有治疗潜力.
向肌肉菌素可能为治疗肌肉消耗疾病提供一种新的策略.

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