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Updated: Aug 11, 2026

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在芯片上进行三维人类神经培养,回顾神经炎症和神经退行

You Jung Kang1,2, Yen N Diep1,2,3, Minh Tran1,2,3

  • 1Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea.

Nature protocols
|August 4, 2023
PubMed
概括

我们开发了一个人脑芯片模型,用于研究神经系统疾病中的神经炎症. 这种先进的模型揭示了免疫细胞激活如何导致大脑损伤,提供了新的治疗见解.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...