CSF1R调节精神分裂症相关的应激反应和微质/巨细胞的血管协会
Ling Yan1, Yanli Li2, Fengmei Fan2
1Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
BMC medicine
|August 4, 2023
概括
微细胞和殖民地刺激因子1受体 (CSF1R) 通过影响压力和大脑血管发育,在精神分裂症中发挥作用. 在小鼠中抑制CSF1R增加了焦虑和改变了微质功能.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 微质细胞调节压力和焦虑,但它们在精神分裂症中的作用尚不清楚.
- 心理社会压力是精神分裂症的关键危险因素.
- 这项研究调查了微质/巨细胞在精神分裂症中通过应激易感性发挥的作用.
研究的目的:
- 通过压力调节探索微质效应分子在精神分裂症中的参与.
- 研究殖民地刺激因子1受体 (CSF1R) 与精神分裂症之间的关联.
- 在小鼠模型中检查CSF1R抑制对压力和焦虑的影响.
主要方法:
- 招募了第一发精神分裂症 (FES) 患者和健康对照 (HCs).
- 进行了血液RNA测序,脑部MRI,并测量了血CSF1R水平.
- 利用一种患有慢性不可预测压力 (CUS) 的小鼠模型与CSF1R抑制剂 (CSF1Ri).
主要成果:
- 与HC相比,FES患者表现出更高的压力感知,更低的CSF1R水平,以及减少的大脑体积.
- 在HC患者中,CSF1R水平与大脑结构和压力感知相关,但不是FES患者.
- 在小鼠中,CSF1Ri治疗加剧了焦虑,减少了大脑血管生成,改变了微质形态.
结论:
- 微质/巨体CSF1R与精神分裂症相关的压力和大脑血管生成有关.
- 研究结果表明,CSF1R是理解精神分裂症病理生理学的潜在目标.
- 在精神分裂症中,微质功能和应激反应密切相关.
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