通过来自小猪肠道的特定微生物调节血清素的产生
Ziyu Liu1,2, Yidan Ling1,2, Yu Peng3
1Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Journal of animal science and biotechnology
|August 4, 2023
概括
猪肠中的Lactobacillus amylovorus与血清素的产生有积极的相关性. 微生物代谢物,如酸盐,通过影响肠道细胞中关键基因表达来调节这种调节,为控制血清生物合成提供了一种新方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 血清素调节肠道分泌和感官功能.
- 肠道微生物群会影响血清的合成,但小猪的机制尚不清楚.
- 这项研究研究了猪结肠中的微生物群与血清素相互作用.
研究的目的:
- 探索肠道微生物群与小猪中血清素生产之间的关系.
- 为了确定特定的微生物和调节肠道血清素的机制.
- 研究微生物代谢物在宿主-微生物通信中的作用.
主要方法:
- 经过阴道导管的猪仔接受了抗生素或盐水输液.
- 分析了微生物组成和血清素水平.
- 培养了微生物菌株,并评估了它们对肠道细胞系 (IPEC-J2,RIN-14B) 的影响.
- 测试了特定的微生物代谢物对它们对基因表达和血清素生产的影响.
主要成果:
- 抗生素治疗增加了Lactobacillus amylovorus (LA) 和结肠中的血清素.
- LA,Limosilactobacillus reuteri (LR) 和Streptococcus alactolyticus (SA) 超级生物在IPEC-J2细胞中调节TPH1表达和血清素;只有LA在RIN-14B细胞中具有这种作用.
- 乙酸,一种微生物代谢物,在肠道细胞中高调自由脂肪酸受体3和TPH1,低调里胺2,3-二氧化酶1.
结论:
- 乳酸氨酸菌与猪肠中血清素的产生有积极的相关性.
- 微生物代谢物,如酸盐,调解宿主-微生物通信,以调节血清生物合成.
- 微生物操纵是控制肠道血清水平的潜在策略.
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