药物过量数据分析:对FDA不良事件报告系统 (FAERS) 中的药物错误报告的审查
Jiaqi Ni1,2,3, Xinru Tang3, Li Chen4,5
1Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
BMC pharmacology & toxicology
|August 4, 2023
概括
过量服用药物是一种严重的药物错误. 在过量服用事件中,阿片类止痛药和抗发烧药/止痛药是最常见的,这凸显了改善药物安全措施的必要性.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 药物错误分析 药物错误分析
背景情况:
- 药物过量是普遍存在的药物错误,对患者造成重大伤害和经济影响.
- 美国食品和药物管理局的不良事件报告系统 (FAERS) 是监测药物安全性的关键数据库.
- 识别经常涉及过量服用的药物对公共卫生至关重要.
研究的目的:
- 为了在FAERS数据库中识别在过量事件中最频繁报告的药物.
- 确定与药物过量相关的前10个药物类别.
- 为预防药物过量使用的策略提供信息.
主要方法:
- 在FAERS数据库中进行了全面的搜索,查找2017年第一季度至2021年第四季度的药物过量记录.
- 描述性分析量化了每种药物过量报告的总数和百分比.
- 亚组分析检查了不同药理学分类中的过量使用风险.
主要成果:
- 获取了170,424份药物过量报告.
- 抗发烧药和止痛药代表了最高的风险组 (37.05%),阿片类药物是最有影响的.
- 前十大药物类别包括阿片类止痛药,化物抗炎止痛药和5-HT再吸收抑制剂.
结论:
- 药物过量事件,特别是涉及止痛药和阿片类药物,需要有针对性的安全干预措施.
- 处方前审查和加强药物安全教育等策略可以减轻过量服用的风险.
- 制定高风险药物的警告清单是防止未来过量服用事件的关键一步.
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