转基因组学揭示了肠道菌群与自闭症谱系障碍的相关性
Khashayar Shahin1, Abbas Soleimani-Delfan2, Zihan He1
1Center for Microbes, Development, and Health (CMDH), Institute Pasteur of Shanghai/Chinese Academy of Sciences, Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai, 200031, China.
Gut pathogens
|August 4, 2023
概括
患有自闭症谱系障碍 (ASD) 个体的肠道菌群显示出更大的多样性和丰富性,特别是在Caudoviricetes菌中. 这些菌体差异可能成为ASD的潜在诊断生物标志物.
科学领域:
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
- 胃肠病学 胃肠病学
背景情况:
- 人的肠道微生物组显著影响健康和疾病.
- 肠道菌体 (感染细菌的病毒) 在人类健康中的作用尚未得到充分研究.
- 肠道微生物群的改变可能与自闭症谱系障碍 (ASD) 有关.
研究的目的:
- 调查肠道菌群与自闭症谱系障碍 (ASD) 之间的关联.
- 为了确定潜在的体生物标志物用于ASD诊断.
主要方法:
- 从公共肠道微生物群数据库中分析菌体蛋白编码单元 (pPCU).
- 从中国队列中,与ASD和典型发育 (TD) 个体之间的菌体多样性和丰富性的比较.
主要成果:
- 与TD个体相比,ASD个体的肠道菌群表现出明显更高的多样性和丰富性.
- 在ASD组中观察到Caudoviricetes细菌菌体的显著扩张.
- 针对Bacteroidaceae的菌体和Faecalibacterium内的菌体在ASD患者中更为普遍.
结论:
- 肠道菌群的组成在ASD和TD个体之间存在显著差异.
- 这些菌体差异,包括增加的多样性和特定的菌体扩张,可以作为ASD的潜在诊断生物标志物.
- 需要进一步的研究来阐明肠道菌体社区在ASD病原体中的确切作用.
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