评估脉冲电磁疗法对疼痛糖尿病远距离对称外周神经病变的影响:双盲随机对照试验
Erica E Tassone1, Jeffrey C Page1, Marvin J Slepian2,3
1Regenesis Biomedical Inc., Scottsdale, AZ, USA.
Journal of diabetes science and technology
|August 5, 2023
概括
脉冲电磁场疗法 (PEMF) 显著减少了糖尿病神经病变患者的疼痛. 这种非药物治疗有望改善血液循环和管理糖尿病并发症.
科学领域:
- 生物医学工程 生物医学工程
- 临床医学 临床医学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病对称外围神经病变 (DSPN) 导致显著的疼痛和感官损失.
- 对DSPN的有效疼痛管理仍然是一个临床挑战.
- 周围动脉疾病 (PAD) 是一种常见的糖尿病并发症,影响小循环.
研究的目的:
- 调查脉冲电磁场疗法 (PEMF) 对DSPN患者减轻疼痛的疗效.
- 评估PEMF对皮肤 perfusion 压力 (SPP) 的影响,作为血管功能的指标.
主要方法:
- 一个随机的,模拟控制的,双盲的临床试验,涉及182名糖尿病患者和DSPN.
- 18周的PEMF或假疗法治疗期,每天两次30分钟.
- 收集了每日疼痛评分和2周和7周的SPP测量.
主要成果:
- 在没有治疗中断的患者中,积极的PEMF治疗导致与假药 (P < .05) 相比,疼痛显著减少30%.
- 皮肤输液压 (SPP) 在活跃的PEMF组显示出改善的趋势,尽管在统计学上并不显著.
- 由于设备放置不当,出现过渡性低场强度通知 (LFSN).
结论:
- PEMF治疗是一种潜在的有效的非药物选择,用于管理DSPN疼痛.
- 在糖尿病患者中,PEMF治疗可能对血管生理学和微循环功能障碍有好处.
- 需要进一步的研究来优化PEMF的应用,并确认血管益处.
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