帕金森病的轻微现象 - 患病率,关联和患精神病的风险
Ruth B Schneider1,2, Peggy Auinger1,2, Roseanne D Dobkin3
1Department of Neurology, University of Rochester, Rochester, NY, USA.
Journal of geriatric psychiatry and neurology
|August 5, 2023
概括
轻微的现象在帕金森病 (PD) 中很常见,并预测精神病. 早期识别这些症状可以帮助管理PD精神病风险.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 轻微的现象,如通道现象,存在感和幻觉,在帕金森病 (PD) 中经常观察到.
- 这些经历可能表明PD患者精神病的早期阶段.
- 了解它们的患病率和临床关联对于预测PD精神病至关重要.
研究的目的:
- 确定PD和没有PD的个体中轻微现象的流行率.
- 确定与PD中轻微现象相关的临床因素.
- 评估小现象作为PD中发展精神病的风险因素的作用.
主要方法:
- 在福克斯洞察力队伍中使用了小说精神病和轻度感知障碍问卷对PD (PMPDQ).
- 进行了额外的评估,包括NMSQuest,RBD1Q,MDS-UPDRS Part II以及人口/药物数据.
- 在PD参与者中使用回归模型来分析关联,并在一年内预测事件精神病.
主要成果:
- 轻微现象在PD (43.1%) 中比对照组 (31.7%) 更为普遍.
- 在没有基线精神病的PD患者中,轻微现象与NMSQuest和RBD1Q上的冷漠/注意力/记忆和性功能领域相关.
- 轻微的现象,NMSQuest冷漠/注意力/记忆,和RBD1Q独立预测事件PD精神病.
结论:
- 轻微的现象是帕金森病中常见的现象.
- 这些现象与特定的非运动症状和REM睡眠行为障碍有关.
- 轻微现象的存在是PD患者未来精神病的重要独立预测因素.
相关概念视频
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
746
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
746
Psychological and Sociocultural Causes of Schizophrenia
139
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
139
Parkinson's Disease: Overview
598
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
598
Psychosis and Antipsychotic Drugs: Overview
328
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
328
Parkinson's Disease: Treatment
299
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
299
Positive Symptoms Schizophrenia: Hallucinations and Delusions
102
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
102


