达普托米辛加氧西林治疗持续性甲素敏感性黄金葡萄球菌的细菌病
Wesley D Kufel1,2,3, Zoey Zagoria1, Bruce E Blaine4
1Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, NY, USA.
The Annals of pharmacotherapy
|August 5, 2023
概括
在一小群患者中,达普托米辛加上西林 (D/O) 在两天内有效清除了对甲素敏感的持续性金黄色葡萄球菌菌病 (MSSAB). 这种组合为治疗具有挑战性的MSSAB感染提供了耐受性良好的,节省碳烯的替代方案.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 对于持续性甲素敏感性黄金葡萄球菌菌病 (MSSAB) 的最佳抗生素救援方案仍未确定.
- 目前的方法往往涉及卡巴,这引发了对抗生素管理和Clostridioides difficile感染风险的担忧.
- 需要替代碳烯节约选择,以有效和安全地管理持续性MSSAB.
研究的目的:
- 评估达普素加氧林 (D/O) 作为持续性MSSAB的救援疗法的疗效和安全性.
- 评估接受D/O.的患者的细菌病清除和相关临床结果的时间.
主要方法:
- 一个单一中心的回顾性队列研究包括患有持续性MSSAB (≥72小时阳性血液培养) 的成年患者,接受D/O治疗≥48小时.
- 排除标准包括怀孕,监禁或同时使用其他高活性MSSA抗生素.
- 主要结局是MSSA细菌病清除的时间;次要结局包括微生物治愈,停留时间,死亡率和不良事件.
主要成果:
- 分析了7例患者接触,其中4例涉及内心炎.
- 尽管中位数的细菌病持续时间为7.8天,但中位数的清除是在D/O开始后的2天内实现的.
- 所有患者都实现了微生物治疗,没有报告的不良反应;90天死亡率和再入院率分别为28.6%和14.3%.
结论:
- 达普托米辛加上西林 (D/O) 证明了作为持续性MSSAB的救援方案的有效性和良好的耐受性.
- 这种组合代表了一种潜在的碳烯节约替代品,用于管理难以治疗的MSSAB感染.
- 需要在更大的队列中进行进一步的研究来证实这些发现.
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