脑网络在整个生命周期中的与年龄和性别相关的分散
Qing Wang1, Lingyu Qi1, Cancan He1
1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
GeroScience
|August 5, 2023
概括
年龄和性别在整个生命周期中独特地影响大脑网络连接和拓. 这些大脑网络的变化,特别是静止状态网络 (RSN),可以预测大脑年龄和认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 老年学是一门学科.
背景情况:
- 年龄和性别对健康大脑中大规模静止状态网络 (RSN) 的影响尚未完全理解.
- 研究这些影响对于理解大脑衰老和神经退行性疾病至关重要.
研究的目的:
- 为了检查年龄和性别如何影响大脑网络角色和老化期间的拓性质.
- 探索这些网络特征对大脑年龄和认知衰退的预测能力.
主要方法:
- 在REST-meta-MDD队列中的998名参与者中分析了10个RSN.
- 多变量线性回归用于评估年龄和性别对RSN及其属性的影响.
- 支持向量回归模型使用全脑网络特征来预测大脑年龄和认知衰退.
主要成果:
- 年龄和性别在整个寿命中对大脑网络角色产生了差异性影响.
- 衰老导致 cingulo-opercular,听觉和视觉网络的网络内连接性下降.
- 女性在中年和早期表现出明显的网络模式,在特定网络内和特定网络之间的连接性发生了变化.
- 年龄,但不是性别,降低了大脑网络的总体拓性质.
- 网络特征预测了阿尔茨海默病频谱样本中的大脑年龄和认知障碍.
结论:
- 年龄和性别对整个生命中的动态大脑网络角色和轨迹产生不同的影响.
- 这些发现提高了对与年龄和性别相关的大脑变化的理解.
- 已识别的网络特征可能有助于早期发现痴呆症.
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