在患有全身性硬化症的患者中,食道运动障碍与肺部参与之间的关联:一项回顾性研究
Ylenia Marten Canavesio1, Andrea Pasta2, Francesco Calabrese1
1Gastroenterology Unit, Department of Internal Medicine, University of Genoa, IRCCS-Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Rheumatology international
|August 5, 2023
概括
系统性硬化症患者患有严重的食道运动障碍,如aperistalsis或无效的食道运动,更有可能患上间歇性肺病. 食道功能障碍的严重程度与SSc.中的肺部参与严重程度相关.
科学领域:
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
背景情况:
- 系统性硬化症 (SSc) 是一种罕见的自身免疫性结缔组织疾病,影响多个器官.
- 胃肠道的干扰是常见的,特别是食道功能障碍.
- 间歇性肺病 (ILD) 是SSc患者发病和死亡的主要原因.
研究的目的:
- 调查食道运动障碍与SSc.肺部参与之间的关联.
- 为了确定食道功能障碍在预测ILD严重性的预后价值.
主要方法:
- 对42名SSc患者进行了以芝加哥分类4.0.0的高分辨率计量 (HRM) 的回顾性分析.
- 肺部评估包括功能测试和高分辨率计算机断层扫描 (HrCT) 与沃里克分数.
- 食道收缩性 (DCI) 和ILD严重程度 (HrCT得分) 之间的相关性分析.
主要成果:
- 较高的ILD分数 (Warrick分数≥7) 观察到与正常运动相比,在患有aperistalsis和无效食道运动 (IEM) 的患者中.
- 在食道功能障碍 (DCI) 和ILD严重程度 (HrCT得分) 之间发现了显著的逆相关性.
- 较低的基线下消化道关节压力 (LESP) 与随访时更大的ILD进展相关.
结论:
- 食道运动障碍与系统性硬化症的肺部参与有关.
- 食道功能障碍的严重程度与间歇性肺病的严重程度相关.
- 人力资源管理和ILD评分可以提供有关SSc进展的预后见解.
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