产后乳腺癌的临床特征和预后
Pill Sun Paik1, Jung Eun Choi2, Seok Won Lee3
1Department of Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Breast cancer research and treatment
|August 5, 2023
概括
在分娩后五年内诊断出乳腺癌 (产后乳腺癌) 显示出侵略性特征和较差的生存率. 早期检测和向治疗对于改善这些患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 流行病学 流行病学
背景情况:
- 产后乳腺癌 (PPBC) 被公认为其较差的预后与乳腺癌在其他群体相比.
- 以前的研究表明,PPBC与比年轻女性乳腺癌 (YWBC) 更高的转移率有关.
研究的目的:
- 分析PPBC的临床特征.
- 根据自分娩以来的时间来评估PPBC的预后.
- 确定与PPBC相关的风险因素和结果.
主要方法:
- 来自韩国乳腺癌协会注册表 (2000-2014) 的208,780名乳腺癌患者的回顾性审查.
- 纳入标准:20至50岁的绝经前妇女接受了乳腺癌手术.
- 患者按从第一个出生到癌症诊断的5年间隔分类.
主要成果:
- 在产后5年内诊断的患者 (PPBC <5年) 较年轻,呈现出更先进的阶段,并且具有较低的雌激素受体 (ER) 和孕激素受体 (PR) 表达.
- 在PPBC小于5年的组表现出更高的人体表皮生长因子受体2 (HER2) 阳性率.
- 在PPBC<5年组 (89%) 的5年生存率明显较差,相比于无胎儿 (97.3%) 和较晚的产后诊断组 (93%).
- 多变量分析证实PPBC<5年作为较差生存率的独立预测因素 (HR1.55,p=0.004).
结论:
- 在分娩后五年内诊断出乳腺癌的特点是具有侵略性特征和糟糕的生存结果.
- 对PPBC病理生理学的进一步研究是必不可少的.
- 需要开发新的治疗策略,以提高PPBC患者的生存率.
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