灯两种不同的可变淋巴细胞受体的演变:VLRD和VLRE
Sabyasachi Das1, Thomas Boehm2, Stephen J Holland3
1Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
没有的脊椎动物利用可变淋巴细胞受体 (VLRs) 进行适应性免疫. 研究人员在鱼中发现了两种新的VLR类型,VLRD和VLRE,扩大了我们对其免疫系统的理解.
科学领域:
- 免疫学 免疫学 免疫学
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 没有的脊椎动物具有独特的适应性免疫系统,利用可变淋巴细胞受体 (VLR).
- 已知有三种VLR类型 (VLRA,VLRB,VLRC),其中VLRA/VLRC细胞类似于T细胞,VLRB细胞类似于B细胞.
研究的目的:
- 为了识别和描述灯中的新型VLR类型.
- 研究这些新的VLRs的遗传学关系和基因组合.
主要方法:
- 遗传学分析以确定VLR关系.
- 对VLRD和VLRE组件的基因测序和分析.
- 在淋巴细胞群中对VLRD和VLRE表达的转录分析.
- 对VLRD和VLRE表达细胞的组织分布研究.
主要成果:
- 在鱼中发现了两种新的VLR类型,VLRD和VLRE,它们与VLRA和VLRC有基因关系.
- VLRD和VLRE基因使用39个LRR磁带进行组装,包括VLRA和VLRC基因的磁带.
- VLRD和VLRE转录在三阴性淋巴细胞中最高,也在VLRA+和VLRC+群体中发现.
- 灯中的VLRD+和VLRE+淋巴细胞似乎代表了T型细胞亚系.
结论:
- 兰普雷VLRD和VLRE代表了新的T细胞相关的VLRs,扩大了已知的无脊椎动物适应性免疫的曲目.
- 对于VLRs的组合组装机制是保存和适应在不同的VLR类型和物种.
更多相关视频
10:10Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions
Published on: May 28, 2017
08:54Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
Published on: August 9, 2024
相关概念视频
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Gene Duplication and Divergence
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
LTR Retrotransposons
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Lampbrush Chromosomes
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
Gene Evolution - Fast or Slow?
In contrast, regions which code...
