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脑脊液生物标志物用于预测隔离快速眼动睡眠行为障碍患者的现象转化

Mariana Fernandes¹, Silvia Maio^1,2, Paolo Eusebi³

¹Department of Systems Medicine, University of Rome 'Tor Vergata", Rome, Italy.

|August 5, 2023

概括

患有孤立的快速眼动睡眠行为障碍 (iRBD) 的患者可能预测未来的神经退行性疾病. 较低的CSF Aβ42水平预测了勒维体痴呆症,而血脑屏障的改变预测了帕金森病.

科学领域:

神经学神经学
神经科学是一个神经科学.
生物标志物研究生物标志物研究

背景情况:

患有孤立的快速眼动睡眠行为障碍 (iRBD) 的患者面临患神经退行性疾病的风险增加.
在iRBD中早期识别表转化风险对于及时干预至关重要.

研究的目的:

在iRBD患者中评估脑脊液 (CSF) 生物标志物用于神经退行和血脑屏障 (BBB) 改变.
确定这些生物标志物是否可以预测转化为α-synucleinopathies的现象转化,如帕金森病 (PD),勒维体痴呆症 (DLB) 和多重系统缩 (MSA).

主要方法:

在iRBD患者和对照者中比较了CSF生物标志物 (Aβ42,tau) 和BBB完整性 (CSF/血清白蛋白比率).
跟踪iRBD患者,将他们分类为转换者 (cRBD) 或非转换者 (ncRBD) 到α-synucleinopathies.
利用考克斯回归分析来识别用于转换的预测生物标志物.

主要成果:

与对照组相比,iRBD患者的CSF Aβ42水平较低,CSF/血清白蛋白比较高.
随着运动障碍的严重程度,转换率的增加.
较低的CSF Aβ42水平预测了DLB转换 (HR=0.67,p=0.038);较高的BBB变化预测了PD转换 (HR=1.20,p=0.038).

结论:

在iRBD患者中,CSF的Aβ42水平和BBB完整性分别是DLB和PD转变的潜在预测因素.
这些发现表明,CSF生物标志物可以帮助区分iRBD中的转化途径.
需要进一步的研究来验证这些预测生物标志物的能力.

关键词:

雷姆睡眠行为障碍雷姆睡眠行为障碍阿尔法-同核蛋白病变的发生.生物标志物生物标志物在纵向的长度上.神经发育性疾病神经发育性疾病

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