双极性疾病中的加速衰老:对六个表观遗传钟的探索性研究
Céline Bourdon1, Bruno Etain2, Luana Spano1
1Université Paris Cité, Inserm, Optimisation Thérapeutique en Neuropsychopharmacologie, F-75006 Paris, France.
Psychiatry research
|August 5, 2023
概括
双相情感障碍 (BD) 患者表现出加速表观遗传衰老. 像BMI,性别,吸烟和童年虐待等因素与这种加速衰老相关,突出了BD中明显的表观遗传时钟敏感性.
科学领域:
- 精神病学是一个精神病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 双极性障碍 (BD) 是一种严重的精神疾病,与增加的医疗问题和更短的寿命有关.
- 加速表观遗传衰老是慢性疾病中健康状况的潜在生物标志物.
研究的目的:
- 通过使用基于多重DNA甲基化 (DNAm) 的表观遗传时钟,研究双相情感障碍 (BD) 患者的加速表观遗传衰老.
- 确定与 BD 中表观遗传衰老加速相关的因素.
主要方法:
- 使用了五个已建立的表观遗传时钟 (Horvath,Hannum,EN,PhenoAge,GrimAge) 和一个基于DNAm的端粒长度时钟 (DNAmTL).
- 通过使用Infinium MethylationEPIC Arrays分析了184名BD个体的全血样本中的DNAm概况.
- 根据DNAm水平得出的估计血细胞计数进行调整.
主要成果:
- 所有六个表观遗传时钟都与时间年龄有显著的相关性.
- 在调整血细胞计数后,表观遗传年龄加速与体重指数显著相关.
- GrimAge和DNAmTL年龄加速与男性性别,吸烟状态和童年虐待有关.
结论:
- 不同的表观遗传钟捕捉了双相情感障碍中衰老过程的不同方面.
- 需要对更大的队列进行进一步的研究和全面的表观遗传时钟分析,以验证这些发现,并探索BD中加速表观遗传衰老的决定因素.
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