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病毒相关的神经内分泌癌症:病原和目前的治疗方法

Juni Banerjee¹, Ramya P Ranjan², Md Tanjim Alam³

¹Institute of Advanced Research, Koba Institutional Area, Gandhinagar, Gujarat 382426, India.

Pathology, research and practice

|August 5, 2023

概括

神经内分泌新生体 (NENs) 涉及瘤病毒,影响患者的预后. 了解这种联系可能会揭示NENs的新的基于病毒的免疫疗法.

科学领域:

在瘤学瘤学.
病毒学病毒学
病理生理学病理生理学

背景情况:

神经内分泌瘤 (NENs) 是日益普遍的恶性瘤,预后不佳.
瘤病毒与NEN发育/进展之间的关联是公认的,但尚未完全理解.
目前对NEN病理生理学及其病毒连接的理解需要进一步阐明.

研究的目的:

探索瘤病毒与神经内分泌新生瘤病理生理学之间的复杂关系.
审查目前对病毒参与NEN发育和进展的理解.
讨论基于病毒的疗法的潜力,如瘤性病毒疗法,用于NEN治疗.

主要方法:

对研究瘤病毒和NENs的综合文献综述.
对神经内分泌瘤 (NETs) 病毒查实验数据的分析.
对NEN病原,分子机制和治疗策略的当前研究进行评估.

主要成果:

一些瘤病毒,包括多瘤病毒,HPV,KSHV和EBV,都与NEN有关.
转移性NEN呈现出不良预后,突出显示了需要有效治疗的需要.
瘤溶解载体在临床研究中显示出有前途,这表明基于病毒的免疫疗法的潜力.

结论:

瘤病毒在NEN病理生理学中发挥着复杂的双重作用.
对NEN病毒相互作用的进一步研究对于开发早期检测和向治疗至关重要.
瘤性病毒疗法和基于病毒的免疫疗法代表了NENs未来有希望的治疗途径.

关键词:

抗病毒疗法抗病毒疗法神经内分泌疾病神经内分泌疾病神经内分泌新生体的神经内分泌新生体瘤学病毒病毒.瘤病毒是什么?病毒疗法病毒疗法

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