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细菌群体与狗的牙周炎和牙周炎有关

Maurício de Oliveira Tavares¹, Lucas Dornelles Dos Reis¹, Wesley Renosto Lopes¹

¹University of Caxias do Sul (UCS), Institute of Biotechnology, Francisco Getúlio Vargas 1130, 95070-560 Caxias do Sul, RS, Brazil.

Research in veterinary science

|August 5, 2023

概括

狗牙周病与口腔细菌的显著变化有关. 研究人员发现了细菌群体的变化,具有不同的口腔微生物组概况,使健康的狗与患有牙炎或牙周炎的狗有区别.

科学领域:

兽医微生物学兽医微生物学
口腔健康研究研究口腔健康研究
狗类牙周科狗类牙周科

背景情况:

牙周病是一种由口腔细菌驱动的慢性炎症状况,影响着狗的健康.
口腔微生物组合的变化与牙周炎和牙周炎的进展有关.
了解这些微生物变化对于诊断和管理狗牙周病至关重要.

研究的目的:

调查与狗牙周病不同阶段相关的可培养口腔微生物群的变化.
描述细菌物种及其在健康,牙炎和牙周炎犬群中的相对丰度.
为了将口腔微生物组的变化与牙周病的严重程度相关联.

主要方法:

从30只健康狗的可培养口腔微生物群分析,牙炎和牙周炎组.
细菌分离,用于分类的16S rRNA基因测序,以及家族遗传树的构建.
多样性 (辛普森指数) 和不相似性 (贾卡德指数) 分析,包括主要坐标分析 (PCoA).

主要成果:

119个细菌分离分为4个类,29个属和45个物种.
在患病的狗中增加了蛋白质细菌的丰富性和减少了Actinobacteria, Firmicutes和 Bacteroidetes.
特定的属 (尼塞里亚,科里尼细菌,帕斯图雷拉,莫拉塞拉) 增加,而斯塔菲洛科克斯随着疾病的进展而减少.
PCoA清楚地将牙周炎病例的口腔微生物组配置文件与健康和牙周炎组分开.

结论:

狗牙周病的特点是口腔微生物组合的显著变化.
该研究确定了与疾病严重程度相关的特定细菌转移,提供了潜在的诊断标记.
独特的口腔微生物组简介可以区分健康的狗和不同程度牙周病的狗.

关键词:

可培养的口腔微生物群狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗牙周病是牙周病的一种疾病.

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