相关实验视频

Updated: Jul 20, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

对IL-10基因多态与急性白血病易感性关联的元分析

Yu-Xin Fan¹, Li-Rong Chen², Run-Xin Gan³

¹Research Center of Clinical Pharmacology, The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China.

|August 5, 2023

概括

干白10 (IL-10) 单核酸多态 (SNP),特别是rs1800896和rs1800872,与急性白血病 (AL) 风险增加有关. 这些IL-10SNP可以作为早期AL查和风险预测的潜在生物标志物.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

越来越多的证据表明Interleukin-10 (IL-10) 单核酸多态 (SNP) 和急性白血病 (AL) 风险之间存在联系.
之前的研究已经产生了有争议的发现,需要进一步调查IL-10SNP在AL敏感性中的确切作用.

研究的目的:

进行全面的元分析,以澄清IL-10SNP与患急性白血病的风险之间的关联.
确定特定的IL-10SNP,这些SNP可以作为AL的预测生物标志物.

主要方法:

在六个主要的中英文数据库中进行了系统的文献搜索.
使用Review Manager (版本5.3) 和STATA (版本15.1) 进行了元分析,以计算赔率比率和95%置信区间.
这项研究以CRD42022373362.2号注册.

主要成果:

rs1800896的AG基因型与异合性共主导和超主导模型中AL风险增加有关 (分别OR=1.41,P=0.03;OR=1.32,P=0.03).
亚组分析显示了rs1800896的G等位基因,GG基因型和AG基因型之间的关联,以及混合种群中的各种遗传模型中AL风险升高.
在超主导模型下,rs1800872的AC基因型与白人的AL风险增加有关,而其他测试的SNP (rs1800871,rs3024489,rs3024493) 并没有显著影响AL风险.

结论:

IL-10 SNPs rs1800896和rs1800872显著影响对急性白血病的易感性.
这些特定的IL-10多态表现出作为AL早期查和风险分层的有价值生物标志物的潜力.

关键词:

患有急性白血病的人.介质蛋白-10 介质蛋白-10 是一种进行元分析分析.单个核酸的多态性.易感性易感性易感性

更多相关视频

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...