免疫衰老 - - 自免疫性疾病的一个机制
Yanyan Zheng1, Qingxiang Liu2, Jorg J Goronzy3
1Department of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN, USA.
Seminars in immunology
|August 5, 2023
概括
免疫衰老通过引起细胞功能障碍,促进自身免疫. 修复线粒体和溶解体可能为自身免疫性疾病提供新的治疗方法,如类风湿性关节炎和巨细胞动脉炎.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 这是一种自身免疫力.
背景情况:
- 免疫衰老与自身免疫能力的增加有关.
- 由于血液形成,淋巴发生和环境暴露,免疫系统在一生中发生变化.
- 老年人表现出对感染和瘤的反应受损,但积累了老化的免疫细胞,包括产生自身抗体的与年龄相关的B细胞.
研究的目的:
- 审查将免疫衰老与自身免疫性联系起来的证据.
- 探索与年龄相关的自身免疫性疾病背后的细胞机制.
- 为了确定自身免疫性疾病的潜在治疗点.
主要方法:
- 审查新出现的科学证据.
- 对免疫衰老中的细胞过程的分析.
- 专注于特定的自身免疫性疾病:类风湿性关节炎和巨细胞动脉炎.
主要成果:
- 免疫衰老导致老化的T细胞,B细胞和骨髓状细胞的积累.
- 细胞衰老涉及基因组不稳定性,线粒体功能障碍,蛋白质稳定性受损和自性减少.
- 功能不良的线粒体,溶解体和内 плазма网膜有助于致病性免疫细胞驱动类风湿性关节炎和巨细胞动脉炎.
结论:
- 免疫衰老是发展自身免疫性疾病的重要危险因素.
- 细胞衰老过程,特别是线粒体和溶酶体功能障碍,是自身免疫的关键驱动因素.
- 针对细胞修复机制,如线粒体和溶酶体,为自身免疫性疾病提供了一个有前途的治疗策略.
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