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Updated: Jul 20, 2025

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1,2,3-二醇衍生的潜在抗疟疾支架的当前发展:结构-活性关系 (SAR) 和生物活性化合物

S Maheen Abdul Rahman1, Jasvinder Singh Bhatti2, Suresh Thareja1

  • 1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, 151401, Punjab, India.

European journal of medicinal chemistry
|August 5, 2023
PubMed
概括

耐药疟疾需要新的治疗方法. 基于triazole的混合分子显示出作为下一代抗疟疾药物的前景,提供了对抗Plasmodium寄生虫的独特机制.

关键词:
这是一种抗疟疾药.异环化合物 异环化合物传染病 传染病 传染病疟疾:疟疾是一种疾病.原菌 (Plasmodium falciparum) 是一种有毒的病毒.奎诺林 (quinoline) 是一种氨酸.这种药物是三醇.

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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
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Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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