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精神病风险因子RBM12编码了一个新的抑制器GPCR/cAMP信号传导的抑制器

Khairunnisa M Semesta1, Angelica Garces1, Nikoleta G Tsvetanova1

  • 1Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA.

The Journal of biological chemistry
|August 5, 2023
PubMed
概括

RNA结合蛋白12 (RBM12) 调节了G蛋白结合受体/cAMP/蛋白激酶A信号传递. 失去RBM12会导致神经元信号通路的过度活跃,这可能解释了它在精神分裂症和精神病中的作用.

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