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儿科炎症性肠病的流行病学
Rabia Khan1, M Ellen Kuenzig2, Eric I Benchimol3
1SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), 555 University Avenue, Toronto, ON M5G 1X8, Canada.
儿童炎症性肠病 (IBD) 在全球范围内正在上升. 饮食,抗生素和污染等环境因素可能会在遗传敏感的儿童中引发IBD,影响肠道健康.
科学领域:
- 胃肠道学和免疫学
- 儿科健康 儿科健康
- 环境医学 环境医学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,是一种慢性炎症性疾病.
- 世界各地的儿童和青少年越来越多地被诊断出IBD.
- 遗传倾向与环境因素相结合,通过对肠道微生物群的失调的粘膜免疫反应触发IBD.
研究的目的:
- 提供儿科发病IBD的流行病学概述.
- 探索各种环境风险因素,有助于儿童IBD的发展.
- 综合当前关于影响儿科IBD发病率的因素的知识.
主要方法:
- 文献综述和关于儿科IBD的流行病学数据的综合.
- 环境暴露的分析及其与IBD发展的关联.
- 讨论儿科IBD的既定和新兴风险因素.
主要成果:
- 全球儿科IBD的发病率和患病率正在增加.
- 涉及的关键环境因素包括卫生假设,空气污染,减少对绿色空间和蓝色空间的暴露,新生儿因素,抗生素使用和饮食模式.
- 这些因素与宿主基因相互作用,影响肠道免疫系统.
结论:
- 了解儿科IBD流行病学对于公共卫生倡议至关重要.
- 环境因素在儿科IBD的上升率中发挥着重要作用.
- 进一步研究特定的环境触发因素及其机制是有必要的,以告知预防和治疗策略.
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