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微质中的溶酶体酸化功能障碍:神经炎症和神经退行症的新兴致病机制

Joseph D Quick¹, Cristian Silva², Jia Hui Wong³

¹Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, USA.

Journal of neuroinflammation

|August 5, 2023

概括

微质细胞中的 lysosomal 酸化受损会破坏大脑免疫细胞的功能,导致神经炎症和神经退行. 恢复 lysosomal pH 可能会逆转这些有害影响.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

微质细胞是大脑的免疫细胞,对通过细胞形成的中枢神经系统防御至关重要.
溶解体酸化对于微质清除废物和有毒蛋白质至关重要.
微质细胞中的 lysosomal 功能受损与神经炎症和神经退行有关.

研究的目的:

审查受损的微质 lysosomal 酸化的机制.
探索微质功能障碍和神经退行症之间的联系.
讨论恢复 lysosomal 功能的治疗策略.

主要方法:

文献综述综合了关于微质 lysosomal 功能的当前研究.
对导致 lysosomal 酸化缺陷的因素的分析.
讨论监测 lysosomal pH 和治疗干预的技术.

主要成果:

缺陷的溶酶体酸化会损害微质细胞和自.
这种功能障碍使神经炎症延续,并加剧神经退行.
lysosomes 的重新酸化可以逆转神经退行性病理,例如,在阿尔茨海默氏症.

结论:

微质 lysosomal 酸化是大脑恒温的关键调节者.
针对溶酶体再酸化的治疗策略对神经退行性疾病具有前景.
对溶酶体-线粒体和神经元-质细胞相互作用的进一步研究是必要的.

关键词:

酸性纳米颗粒酸性纳米颗粒自自是一种自的过程.细胞因子 (cytokines) 是一种细胞因子.Lysosomal 酸性化发生的原因神经退行性疾病的神经退行性疾病神经炎症是一种神经炎症.发细胞症 (phagocytosis) 是一种致死细胞的发生.有毒的蛋白质聚合物

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