在亚洲青少年中,维生素D和维生素D受体多态性发生在患有原发性经期障碍的亚洲青少年中
Ainur Donayeva1, Ainur Amanzholkyzy1, Roza Nurgaliyeva1
1Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
BMC women's health
|August 5, 2023
概括
低维生素D水平和特定的维生素D受体 (VDR) 基因变异与亚洲青少年的原发性经期障碍有关. 下血清25(OH) D和VDRT/t或t/t基因型增加了疼痛月经的风险.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 生殖健康 生殖健康
背景情况:
- 在子宫内膜和卵巢中维生素D受体表达表明在局部免疫和炎症中起作用.
- 建立了维生素D对炎症性细胞因子的影响.
- 当地免疫和炎症调节是妇科健康的关键因素.
研究的目的:
- 为了研究血清25(OH) D水平和亚洲青少年的原发性经期障碍之间的联系.
- 为了确定维生素D受体 (VDR) TaqI (rs731236) 多态性和原发性更年障碍之间的关系.
- 探索维生素D状况和VDR基因型对异常症严重性的综合影响.
主要方法:
- 一项前性研究比较了205名患有原发性经期障碍的青少年和210名匹配的对照.
- 测量了血清25(OH) D水平,并进行了VDR TaqI (rs731236) 基因定型.
- 皮尔森的相关性被用来分析血清25(OH) D和异常更年期严重程度 (视觉模拟尺度) 之间的关系.
主要成果:
- 与对照组相比,患有原发性经期障碍的青少年的血清25(OH) D水平显著降低 (16.17±7.36对比17.65±6.36 ng/ml,P=0.01).
- 在血清25 (((OH) D和异常经期严重程度 (r=-0.9003,P<0.0001) 之间发现了显著的负相关性.
- VDR T/t和t/t基因型与较低的血清25(OH) D相关,并显著增加了原发性经期障碍的几率 (分别为OR 1367.2,P<0.0001和OR 106.2,P=0.001).
结论:
- 较低的血清25(OH) D水平与亚洲青少年的原发性经期障碍明显相关.
- 特定的维生素D受体 (VDR) TaqI多态性 (T/t 和 t/t) 与增加初级失经症的风险和严重程度有关.
- 这些发现凸显了维生素D及其受体在异常更年期症病理生理学中的潜在作用.
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