血清脂卡林2的较高水平与卒中后的抑郁症有关,在放电时
Yufeng Liu1, Lu Liu1, Zhongwen Zhi1
1Department of Neurology, Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, South Huaihai Road, Huai'an 223002, Huai'an, 223002, Jiangsu, China.
BMC neurology
|August 5, 2023
概括
在入院时,高血清卡林2 (LCN2) 水平与急性缺血性中风 (AIS) 患者患中风后抑郁症 (PSD) 的风险增加有关. 这一发现表明,LCN2可能作为PSD的预测生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 脑卒中后抑郁症 (PSD) 是一种常见的并发症,影响患者的康复和预后.
- 炎症调解剂与PSD的发展有关.
- 利波卡林2 (LCN2) 是一种急性阶段蛋白质,涉及急性缺血性中风 (AIS) 和抑郁症.
研究的目的:
- 研究AIS患者入院时血清LCN2水平与出院时PSD发生之间的关系.
- 确定血清LCN2是否可以作为PSD的预测生物标志物.
主要方法:
- 追溯研究包括358名AIS患者.
- 在入院后24小时内测量出的血清LCN2水平.
- 在出院前使用17项汉密尔顿抑郁量表 (HAMD) 诊断的PSD (HAMD分数>7).
- 二元逻辑回归分析用于评估血清LCN2和PSD之间的相关性.
主要成果:
- 92名患者 (25.7%) 在出院时被诊断患有PSD.
- 高血清LCN2水平 (Tertile 3) 在调整混因子后,独立地与PSD风险增加有关 (OR = 2.639,P = 0.006).
- 血清LCN2预测PSD的最佳切断值为117.60 ng/ml,敏感度为77.2%,特异性为53.4%.
结论:
- 入院时血清LCN2水平升高是AIS患者PSD发展的独立风险因素.
- 血清LCN2显示出作为中风后抑郁症预测生物标志物的潜力.
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