绝经后妇女骨质疏松性骨折的预测因素:一个元分析
Guanghua Long1, Chong Liu1, Tuo Liang1
1Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Journal of orthopaedic surgery and research
|August 5, 2023
概括
这项元分析确定了绝经后妇女骨质疏松性骨折的关键预测因素,包括年龄和BMI. 这些发现有助于早期预测风险并制定骨质疏松症的预防策略.
科学领域:
- 老年病学和妇女健康
- 流行病学 流行病学
- 代谢性骨病 代谢性骨病
背景情况:
- 骨质疏松症严重影响全球超过2亿名妇女,绝经后妇女面临更高的骨折风险.
- 目前的骨质疏松症管理往往优先考虑症状治疗而不是预防措施.
- 确定预测因素对于早期风险评估和绝经后妇女的有针对性的干预措施至关重要.
研究的目的:
- 进行元分析,确定绝经后妇女骨质疏松性骨折的预测因子.
- 为了促进高风险个体的早期预测.
- 探索骨质疏松症的潜在治疗和预防策略.
主要方法:
- 进行了对队列和病例控制研究的综合元分析.
- 在Embase,MEDLINE和Cochrane数据库中使用特定的关键字进行搜索.
- 分析了10项符合条件的研究,涉及超过120万名绝经后妇女.
主要成果:
- 骨质疏松性骨折的重要预测因素包括晚年,较低的BMI,较高的平价值,以及高血压或糖尿病史.
- 早期或晚期初潮/更年期,酒精摄入,雌激素使用和维生素D补充等因素也显示了相关性.
- 年龄,BMI,平价,高血压,糖尿病,酒精摄入量,初潮/绝经年龄,雌激素使用和维生素D与骨折风险有显著联系.
结论:
- 鉴定到的预测因素使得能够早期识别患有骨质疏松性骨折高风险的绝经后妇女.
- 研究结果支持制定有针对性的预防策略和潜在的治疗方法.
- 减少骨质疏松症的负担需要专注于预防和早期风险评估.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
09:02Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
Published on: January 31, 2025
547
相关概念视频
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:40Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:28Menopause
201
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
201
01:25Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K
01:31Essential Minerals for Bone Health
4.1K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.1K