母亲的身体活动,坐着,以及非心脏出生缺陷的风险
Kelly R Evenson1, Sanjida Mowla2, Andrew F Olshan2
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina - Chapel Hill, Chapel Hill, NC, USA. kelly_evenson@unc.edu.
Pediatric research
|August 5, 2023
概括
母亲怀孕前的身体活动与较少的出生缺陷有关,而较少的坐时间与某些缺陷的几率降低有关. 需要进一步的研究来证实这些发现,并了解机制.
科学领域:
- 生殖健康 生殖健康
- 流行病学 流行病学
- 出生缺陷的研究研究研究.
背景情况:
- 母亲怀孕前的身体活动 (PA) 和带有出生缺陷的坐着行为之间的联系仍未得到充分研究.
- 这项研究调查了母亲PA和怀孕前的坐着习惯以及出生缺陷的发生之间的联系.
研究的目的:
- 检查怀孕前的身体活动与坐着时间以及特定出生缺陷的风险之间的关系.
- 提供对影响怀孕结果的潜在可修改因素的见解.
主要方法:
- 利用了来自美国两项基于人口的病例控制研究的数据:国家出生缺陷预防研究 (NBDPS) 和出生缺陷研究以评估怀孕暴露S (BD-STEPS).
- 包括12例非心脏出生缺陷的病例 (n=3798) 和没有重大出生缺陷的对照 (n=2682).
- 用无条件逻辑回归分析了母亲自我报告的妊娠前的PA和坐着的数据.
主要成果:
- 孕前母亲的体力活动与五种出生缺陷的几率降低 (分脊椎,口腔裂,阳门缩,缺血,横截肢缺陷) 和两种 (无脑症,胃) 的几率增加有关.
- 减少怀孕前的坐着时间与两种出生缺陷的几率较低 (阳肠缩,下) 和一个 (带有或没有裂口口唇) 的几率较高有关.
结论:
- 研究结果表明,怀孕前的生活方式因素与出生缺陷发生之间存在潜在的关联.
- 建议通过改进的暴露评估和机制研究进行进一步的研究,以确认和理解.
- 这些发现在多样化的群体中复制是至关重要的.
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