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系统性免疫炎症指数:在区分不同甲状腺疾病的新标志物
Selahattin Vural1, Ali Muhtaroğlu1, Mert Güngör1
1Department of General Surgery, Faculty of Medicine, Giresun University, Giresun, Turkey.
Medicine
|August 6, 2023
概括
系统性免疫炎症指数 (SII),从全血细胞计 (CBC) 中计算,在乳头甲状腺癌 (PTC) 患者中显著升高. 这种标记可以帮助区分良性和恶性甲状腺疾病.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 炎症与癌症的发展有关,包括甲状腺恶性瘤.
- 系统性免疫炎症指数 (SII) 是一种从全血细胞计 (CBC) 参数获得的新型标记.
- 区分良性和恶性甲状腺疾病对于有效的患者管理至关重要.
研究的目的:
- 调查SII与各种甲状腺疾病之间的关联.
- 确定SII是否可以区分良性甲状腺疾病和乳头甲状腺癌 (PTC).
主要方法:
- 241名接受甲状腺手术的患者的回顾性评估 (2018年1月至2022年1月).
- 根据病理学,患者被分类为多节 (n=125),淋巴细胞甲状腺炎 (n=44) 和PTC (n=73).
- SII计算为 (中性粒细胞 ×血小板) / 淋巴细胞.
主要成果:
- 与良性甲状腺疾病组相比,PTC组的SII水平显著更高 (P < .001).
- 接收器操作特征 (ROC) 分析确定了654.13的最佳SII截止值来区分PTC,其灵敏度为73.8%,特异性为72.3%.
- 根据子组分析中的PTC临床病理特征,SII水平没有显著差异.
结论:
- 与良性甲状腺疾病患者相比,PTC患者的术前SII水平较高.
- SII是一种简单,易于使用的标记物,可以帮助对良性与恶性甲状腺疾病的差异诊断.
- 进一步的研究可能会探索SII在预测甲状腺癌结果中的作用.
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