硫暴露的眼科并发症和管理方法:叙述性审查
Seyed Hosein Ghavami Shahri1, Mahdi Balali-Mood2, Hamid Reza Heidarzadeh1
1Eye Research Center, Mashhad University of Medical Sciences, Birjand, Iran.
Archives of Iranian medicine
|August 6, 2023
概括
暴露于硫 (SM) 可以导致长期的眼睛损伤,没有明确的治疗方法. 目前的治疗重点是对各种眼部并发症进行支持性医疗和手术管理.
科学领域:
- 眼科医生 眼科 眼科
- 毒理学 毒理学 毒理学
- 化学武器制剂 化学武器制剂 化学武器制剂
背景情况:
- 硫 (SM) 是一种强大的化学战剂,对眼睛,皮肤和呼吸系统造成严重的长期损伤.
- 暴露于MS的眼部并发症可以在几年后表现出来,即使在无症状的个体中,通常需要手术干预.
研究的目的:
- 审查当前对硫暴露引起的急性和长期眼部并发症的理解和管理策略.
- 突出持续缺乏有效治疗方法,并探索替代治疗方法.
主要方法:
- 关于SM引起的眼损伤的实验和临床研究的综合文献综述.
- 对特定并发症的各种医疗和外科干预措施的分析,如干眼,持续的上皮质缺陷 (PED),四肢干细胞缺乏 (LSCD),角膜血管化和不透明.
主要成果:
- 尽管进行了数十年的研究,但对于SM引起的眼部并发症没有普遍有效的治疗方法.
- 针对特定情况,使用各种治疗方法,包括滑,羊水膜移植,干细胞疗法,类固醇,抗VEGF药物和角膜移植.
- 富血小板血,光动力疗法,黄素和干细胞衍生物等替代疗法显示出有前途,但需要进一步调查.
结论:
- 暴露于硫 (SM) 的眼部并发症仍然是一个重大的临床挑战,有效的治疗选择有限.
- 支持性医疗和手术管理提供了症状缓解,可以改善结果,但长期的后果仍然存在.
- 对新型治疗策略的持续研究对于开发SM诱导的眼睛损伤的有效治疗方法至关重要.
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