晚期多发性硬化症的临床和流行病学方面在东阿塞拜疆,伊朗; 一个基于人口的研究
Ehsan Nasiri1, Amirreza Naseri1, Pouya Abbasgholizadeh1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Archives of Iranian medicine
|August 6, 2023
概括
晚发性多发性硬化症 (LOMS) 影响4.42%的患者,通常在50-55岁之间发病. 早期症状因性别而异,女性的运动问题更常见,男性的小脑问题更常见.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 晚发性多发性硬化症 (LOMS) 被定义为50岁后开始的多发性硬化症 (MS) 症状.
- LOMS代表了MS病例的重要子集,需要特定的临床和流行病学理解.
研究的目的:
- 调查LOMS在伊朗东阿塞拜疆省的临床和流行病学特征.
- 为了确定LOMS的患病率,发病年龄,性别分布和初始临床表现.
- 为了比较男性和女性LOMS患者之间的疾病特征.
主要方法:
- 一项基于人口的研究,利用东阿塞拜疆省唯一的MS注册中心的数据.
- 纳入标准:在50岁或以上被诊断为多发性硬化症的患者,直到2020年底.
- 收集的数据包括患病率,性别,发病年龄,首次临床呈现,家族病史和诊断延迟.
主要成果:
- 在所有MS病例中,LOMS占4.42% (217/4905).
- 发病的平均年龄为53.80±3.41岁,大多数 (69.1%) 是50-55.5岁.
- 女性占比较高 (150对67男性);初始症状在性别之间有显著差异 (P<0.01),女性常见的运动症状和男性的小脑症状.
结论:
- 晚期发病的多发性硬化症不是一种罕见的疾病,需要提高诊断意识.
- 更好的理解和公众意识可以促进早期的LOMS诊断,并减轻长期后果.
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