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相关概念视频

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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Rab Proteins01:14

Rab Proteins

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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
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Rab Cascades01:25

Rab Cascades

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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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The Ras Gene02:38

The Ras Gene

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
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Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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相关实验视频

Updated: Jul 20, 2025

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
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Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

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已激活的STING1可以乘坐Rafeesomeesome.

Yaping Han1, Jianfei Zheng1, Liang Ge1

  • 1The State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China.

Autophagy
|August 6, 2023
PubMed
概括

分泌自促使货物释放而没有溶酶体降解. 通过涉及RAB22A的rafeesome器官分泌的STING1蛋白质可以促进抗瘤免疫力.

科学领域:

  • 细胞生物学 细胞生物学
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 非正规的自利用自机械用于非溶酶体降解途径.
  • 分泌性自是一种非正规的货物分泌途径.
  • STING1蛋白涉及天生的免疫力和炎症.

研究的目的:

  • 为了研究分泌性自在STING1蛋白质分泌中的作用.
  • 确定参与STING1分泌的机制和器官.
  • 探索分泌的STING1.1的免疫后果.

主要方法:

  • 研究了STING1作为分泌性自的基质.
  • 通过RAB22A介导的自细胞和早期内细胞来表征rafeesome细胞器的形成.
  • 评估了含有STING1.1的细胞外囊泡的免疫性.

主要成果:

  • STING1是分泌性自的新型基质.
  • 在STING1分泌中介于RAFEESOME,一个RAB22A依赖的细胞器.
  • 含有STING1的细胞外囊泡诱导抗瘤免疫.

结论:

关键词:
自细胞体自细胞体是自细胞体.埃尔吉克 (ERGIC) 是一种 ERGIC 的形式.在RAB22中使用RAB22.拉菲体育 拉菲体育 拉菲体育 拉菲体育刺痛是一种刺痛.非常规的分泌物 不传统的分泌物

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  • 分泌自和rafeesome通路对于STING1分泌至关重要.
  • RAB22A在STING1分泌中发挥作用,并可能在STING1介导的抗瘤免疫力中发挥作用.
  • 细胞外囊中分泌的STING1可以激活抗瘤免疫反应.