密集血压控制对脑小血管疾病患者认知功能的影响
Bingqing Zhao1, Weihua Jia1, Ye Yuan1
1Department of Neurology, Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University, China.
概括
在患有脑小血管疾病 (CSVD) 的老年患者中,强化血压控制可以延迟认知障碍. 降低缩血压 (SBP) 到126 mmHg,可以减少缺口性心脏病发作 (LI) 和白质超强度 (WMH) 病变.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 大脑小血管疾病 (CSVD) 是患有高血压的老年患者常见的疾病.
- 认知障碍是CSVD的常见并发症.
- 需要有效的CSVD和相关认知衰退的管理策略.
研究的目的:
- 研究密集血压控制对CSVD老年患者认知功能的影响.
- 评估密集血压管理对CSVD神经成像标志物的影响.
主要方法:
- 140名患有CSVD和高血压的老年患者被随机分为标准和密集血压控制组.
- 对患者进行了2年的随访,调整了抗高血压药物的剂量.
- 通过MMSE和MoCA评估认知功能;神经成像评估了缺口性心脏病发作 (LIs) 和白质过强度 (WMH).
主要成果:
- 强化组在2年后,与标准组相比,表现出更好的认知分数 (MMSE,MoCA).
- 密集的血压控制显著降低了WMH和LI.
- 缩血压 (SBP) 和腹缩血压 (DBP) 的降低独立与改善的MMSE得分相关.
结论:
- 与134mmHg相比,将SBP降低到126mmHg可以延迟CSVD的老年高血压患者的认知障碍.
- 密集的血压控制有效地减少LIs和大脑WMH病变.
- 这一策略为管理CSVD患者的认知衰退提供了一个有希望的方法.
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