在怀孕期间对COVID-19疾病的炎症反应的表征
Alexandra D Forrest1, Natalie E Poliektov1, Kirk A Easley2
1Johns Hopkins University, Department of Gynecology and Obstetrics, Baltimore, MD, United States.
Cytokine
|August 6, 2023
概括
有活跃COVID-19感染的孕妇患者表现出增高的促炎细胞因子,类似于非孕妇. 这些升高的炎症标志物,包括IL-10,IL-1β和IL-8,可能与SARS-CoV-2阳性病例的不良妊娠结果有关.
科学领域:
- 免疫学 免疫学 免疫学
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
背景情况:
- 孕妇面临来自COVID-19 (SARS-CoV-2) 感染的更高风险.
- 促炎性细胞因子 (IL-1β,IL-6,IL-8,IL-10) 与非怀孕的COVID-19患者的不良结果有关.
- 细胞因子的升高也与不良妊娠结果,如早产和子宫前有关.
研究的目的:
- 为了比较患有急性/后急性SARS-CoV-2感染的孕妇的血清炎症性细胞因子概况,与之前接触过的患者进行比较.
- 为了调查SARS-CoV-2感染与怀孕期间循环的炎症性标志物之间的关联.
主要方法:
- 对50名已确认感染SARS-CoV-2的孕妇患者进行了回顾性队列研究.
- 母体血清细胞因子水平 (IFN-γ,IL-10,IL-1β,IL-4,IL-6,IL-8,TNF-α) 通过ELISA进行测量.
- 群体根据妊娠年龄进行匹配;使用曼-惠特尼测试比较中位数度.
主要成果:
- 患有急性/后急性感染的患者 (n=22) 与之前接触过的患者 (n=28) 相比,具有更高的IL-10,IL-1β和IL-8.
- 之前暴露的组显示较高的IL-4度.
- 两组之间没有观察到医学并发症的显著差异.
结论:
- 在孕妇中,急性/后急性SARS-CoV-2感染与血清炎症性细胞因子显著增加有关.
- 这些发现表明,SARS-CoV-2在怀孕期间改变了炎症标志物,反映了在非孕妇中观察到的效应.
- 增加的细胞因子水平可能会导致孕妇COVID-19患者的不良产科结果.
相关概念视频
Inflammatory Response I: Vascular and Cellular
11.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.3K
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
COPD: Pathogenesis and Clinical Features
344
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
344
Pneumonia II: Pathophysiology
339
The pathophysiology of pneumonia involves the following steps:
339


