粘粘性皮克林纳米乳液通过动态共价化学
Saul J Hunter1, Mahmoud H Abu Elella2, Edwin C Johnson1
1Dainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, UK.
Journal of colloid and interface science
|August 6, 2023
概括
化物功能纳米颗粒产生粘粘性纳米乳液,强烈附着于鼻组织,显示有希望的向药物输送. 与基功能纳米颗粒相比,这种希夫基化学物质增强了附着性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 纳米技术纳米技术
背景情况:
- 开发有效的药物输送系统需要能够粘附于生物组织的粘膜粘合材料.
- 皮克林纳米乳液为封装疏水药物提供了一个多功能平台.
研究的目的:
- 合成化物功能化纳米颗粒,用于制造粘粘性皮克林纳米乳液.
- 通过希夫基化学评估这些纳米乳液对绵羊鼻腔粘膜组织的粘粘度.
主要方法:
- 双块共聚合物纳米颗粒通过可逆添加-碎片化链转移 (RAFT) 聚合合成.
- 基功能纳米颗粒被氧化成基功能纳米颗粒.
- 石油在水中的皮克林纳米乳液是使用同质化和微流体化形成的.
- 用光显微镜和石英晶微平衡 (QCM) 来评估粘膜粘合.
主要成果:
- 与基功能纳米颗粒涂层的油滴相比,与基功能油滴相比,基功能纳米颗粒涂层的油滴对绵羊鼻腔粘膜组织的粘附性明显更强.
- 希夫基化学 (胺基键形成) 被证实是增强粘膜粘合的机制.
- 初步的生物相容性研究仅显示轻度毒性.
结论:
- 化物功能化的皮克林纳米乳液显示出显著的粘膜粘合,这归因于希夫基形成.
- 这些粘粘性纳米乳液具有将疏水药物局部输送到鼻子组织的潜力.
- 该研究强调了一种用于药物输送应用的功能生物材料设计的新方法.
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