尼亚通过GPR109A依赖机制调节实验性结肠炎中类似抑郁的行为
Walaa Wadie1, Sarah S Mohamed1, Enas A Abd El-Haleim1
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
Life sciences
|August 6, 2023
概括
尼亚是一种维生素B3衍生物,在治疗与炎症性肠病 (IBD) 相关的抑郁症方面表现有前途. 它有助于恢复血脑屏障,并减少大脑中的炎症和氧化应激.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD) 经常与神经系统疾病 (如抑郁症) 一起发生.
- 了解将肠道炎症与大脑功能障碍联系在一起的机制,对于开发有效的治疗方法至关重要.
研究的目的:
- 在大鼠模型中调查氨酸在缓解因大肠炎引起的抑郁症类行为方面的治疗潜力.
- 探索GPR109A及其下游信号通路在尼亚神经保护作用中的作用.
主要方法:
- 大肠炎在使用5%的硫酸 (DSS) 的老鼠中被诱导.
- 尼亚每天服用,有或没有GPR109A阻断剂烯酸化物.
- 进行了行为测试 (开放场地,强迫游泳) 和海马组织的生物化学分析.
主要成果:
- 尼亚显著改善了类似抑郁症的行为,并减少了DSS治疗的老鼠的结肠炎症.
- 尼亚治疗通过增加ZO-1,奥克卢丁和克劳丁-5水平,恢复了血脑屏障的完整性.
- 尼亚调节了海马的氧化应激和炎症标志物,包括降低IL-1β和NF-κB,增加GSH,Sirt-1,Nrf-2和HO-1.
结论:
- 尼亚对大肠炎诱导的类似抑郁的行为产生神经保护作用,部分由GPR109A调解.
- 氨酸的有益作用涉及Sirt-1/Nrf-2/HO-1信号通路,针对神经元氧化应激和炎症.
关键词:
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