夜间的人工光,基于MRI测量大脑的铁沉积和多种精神障碍的发生率
Jianbo Jin1, Wenxing Han1, Teng Yang1
1Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
The Science of the total environment
|August 6, 2023
概括
夜间的人工光 (ALAN) 与成人精神障碍风险增加有关. 大脑铁积累可能会加剧这种关联,强调需要更严格的ALAN标准和有针对性的预防.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 关于大脑铁积累如何影响夜间人工光线 (ALAN) 和精神障碍之间的联系的证据有限.
- 研究这种相互作用对于理解环境对老龄人口心理健康的影响至关重要.
研究的目的:
- 为了检查大脑铁沉积对ALAN暴露和事件精神障碍之间的关联的修饰作用.
- 专注于中年和年长的成年人.
主要方法:
- 使用英国生物库数据和卫星衍生ALAN测量的前性研究.
- 脑铁含量通过敏感度加权的MRI (T2*信号损失) 来评估.
- 时间变化的Cox比例危险模型用于估计精神障碍风险,通过大脑铁含量进行分层分析.
主要成果:
- 更高的ALAN暴露与任何精神障碍,物质使用障碍和抑郁症的风险增加相关.
- 增加ALAN与任何精神障碍的风险增加5.0%有关.
- ALAN与精神障碍之间的关联在特定大脑区域 (左海马,accumbens,pallidum) 铁沉积量高的个体中更强.
结论:
- 艾伦暴露与中年和老年人的多种精神障碍有关.
- 研究结果表明,需要制定更严格的ALAN法规和有针对性的预防策略,特别是在脑铁含量高的人群中.
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