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带血和外围血液衍生的调节性T细胞治疗:在1型糖尿病中的进展

Yuanjie Bi¹, Ran Kong¹, Yani Peng¹

¹National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Hunan Engineering Research Center of Cell Therapy for Diabetes, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

Clinical immunology (Orlando, Fla.)

|August 6, 2023

概括

调节性T细胞 (Tregs) 通过恢复免疫耐受性来治疗1型糖尿病 (T1D) 是有前途的. 然而,在临床应用和扩展中,对于有效的T1D治疗仍然存在挑战.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

调节性T细胞 (Tregs) 对免疫耐受性和调节炎症反应至关重要.
1型糖尿病 (T1D) 是一种自身免疫性疾病,其特征是对胰腺β细胞抗原的自我耐受性丧失.
基于Treg的疗法在T1D等自身免疫性疾病中已经显示出临床前的疗效.

研究的目的:

审查Treg特征,并比较不同的Treg来源.
总结Treg扩展修改用于T1D的临床试验.
讨论Treg采用转移T1D治疗的当前挑战.

主要方法:

从带血液中获得的Tregs与成人外周血液的比较分析.
对Treg扩展用于临床试验的条件修改的审查.
讨论Treg治疗T1D的技术障碍.

主要成果:

Tregs是T1D的可行的治疗候选者,具有已确定的临床前安全性和有效性.
带血和成人外周血液Tregs表现出不同的特征.
目前正在探索用于临床应用的Treg扩张的各种策略.

结论:

收养Treg转移具有T1D治疗的潜力,但临床成功受到现有挑战的阻碍.
进一步研究Treg特征,扩展和传递对于推进T1D免疫疗法至关重要.

关键词:

收养细胞疗法采用细胞疗法.周围血液周围血液监管性T细胞监管性T细胞第1型糖尿病是什么?带血是指带血的血液.

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