在免疫球蛋白G4相关的眼科疾病中对眼表面的评估
Kenneth K H Lai1, Xulin Liao2, Fatema Mohamed Ali Abdulla Aljufairi3
1From the Department of Ophthalmology (K.K.H.L., E.C., C.K.L.K., S.T.C.K.), Tung Wah Eastern Hospital, Hong Kong Special Administrative Region, China; Department of Ophthalmology and Visual Sciences (K.K.,H.L., X.L., F.M.A.A.A., Y.M.W., J.T.C., H.T.M., C.K.M.C., H.K.L.Yl, L.J.C., C.C.T., C.P.P., K.K.L.C.), The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
American journal of ophthalmology
|August 6, 2023
概括
与免疫球蛋白G4相关的眼睛疾病 (IgG4-ROD) 显著影响眼睛表面,导致梅博米腺功能障碍和眼睛干燥. 早期的眼表面评估对于管理IgG4-ROD患者至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 干眼疾病 干眼疾病
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种全身性纤维炎症疾病.
- 在IgG4-RD中,眼睛的参与是常见的,但梅博米腺和眼睛表面的特定变化没有得到很好的描述.
研究的目的:
- 评估免疫球蛋白G4相关眼睛疾病 (IgG4-ROD) 患者中梅博米腺和眼睛表面的功能和结构变化.
主要方法:
- 一项横截式,匹配的病例控制研究比较了64名IgG4-ROD患者和64名健康对照.
- 使用前段检查,角膜学和美图学来评估眼睛表面参数.
主要成果:
- IgG4-ROD 患者表现出显著的角膜染色,眼边缘角膜切除,结膜,乳头和梅腺功能障碍 (插入,表达能力降低,梅质量差).
- 在IgG4-ROD患者中观察到梅博米腺脱落和眼半径高度降低.
- 水性眼缺陷和蒸发性干眼是普遍存在的,患者组的非侵入性眼破裂时间 (NITBUT) 和希尔默测试结果较低.
结论:
- 在IgG4-ROD患者中,存在水性缺陷和蒸发性干眼的综合特征.
- 建议对所有新诊断的IgG4-ROD患者进行眼球表面评估.
- 需要进一步的研究来阐明IgG4相关的干眼疾病背后的机制.
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