爱斯坦·巴尔病毒的表观遗传学 - - 综述
Gadde Shareena1, Dileep Kumar2
1Poona College of Pharmacy, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune 411038, Maharashtra, India.
Biochimica et biophysica acta. Molecular basis of disease
|August 6, 2023
概括
爱斯坦-巴尔病毒 (EBV) 使用DNA甲基化来控制其生命周期,影响宿主细胞并促进癌症的发展. 这篇评论探讨了甲基化.
科学领域:
- 病毒学 病毒学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 在瘤学瘤学.
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 是第一个被确定的人类致癌病毒,与诸如霍奇金淋巴瘤 (HL),伯基特淋巴瘤 (BL),鼻癌 (NPC) 和胃癌 (GC) 等各种癌症有关.
- EBV建立了终身感染,其特点是双相生命周期:持续的潜伏阶段和复制和传播的溶解阶段.
- 表观遗传失调,特别是DNA甲基化,在EBV的致癌潜力及其与宿主细胞的相互作用中起着至关重要的作用.
结论:
- 基因甲基化是EBV生命周期和宿主细胞转变的关键调节者.
- 了解这些基于甲基化的途径对于破译EBV在病变发生中的作用和开发向疗法至关重要.
- EBV复杂的宿主-病原体关系在显著程度上是由表观遗传修饰调解的.
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