麻症,麻性肥胖症和非酒精性脂肪肝疾病
Stergios A Polyzos1, Ilias D Vachliotis1, Christos S Mantzoros2
1First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Metabolism: clinical and experimental
|August 6, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 经常与肉症和肉性肥胖症 (SO) 一起发生,特别是在老年人中. 本综述探讨了这些普遍疾病的联系,临床数据和治疗考虑因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD),肉症和肉性肥胖症 (SO) 很常见,特别是在老年人群中.
- 没有批准的药理疗法存在于所有三个条件同时.
- 病理生理学联系包括阿迪波金,细胞因子,肝因子和肌因子的变化,这些变化受到衰老,饮食和不活动的影响.
研究的目的:
- 审查证据,将肉症和SO与NAFLD联系起来.
- 专注于临床数据和病理生理机制.
- 讨论与NAFLD和肉症/SO同时存在的患者的治疗考虑.
主要方法:
- 观察和队列研究的审查.
- 病理生理学联系的概要.
- 讨论临床数据和治疗策略.
主要成果:
- 大多数观察性研究支持NAFLD和肉症/SO之间的关联.
- 一些队列研究表明,患有NAFLD和肉类的患者的死亡率更高.
- 有限的证据表明,对于没有不良影响的并存条件,可以考虑使用皮奥格利塔或维生素E.
结论:
- NAFLD,sarcopenia和SO经常共存,共享潜在的病理生理机制.
- 临床数据表明存在显著的关联,并可能对死亡率产生影响.
- 治疗策略需要仔细考虑,以管理这些相互关联的条件.
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