动脉曲与血液动力学参数的关联-一项计算流体动力学研究
Kornelia M Kliś1, Dominika Wójtowicz2, Borys M Kwinta1
1Department of Neurosurgery and Neurotraumatology, Jagiellonian University Medical College, Kraków, Poland.
World neurosurgery
|August 6, 2023
概括
内动脉扭曲,在较长的弧线上具有多个小角度的特征,与增加内动脉瘤风险的血液动力学因素相关. 这一发现有助于预测动脉瘤的发展.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 医疗成像医学成像
背景情况:
- 内动脉扭曲与内动脉瘤发展风险增加有关.
- 了解扭曲影响血液动力学的具体几何方面对于动脉瘤风险评估至关重要.
研究的目的:
- 分析动脉曲的特定特征与与内动脉瘤发育相关的血液动力学参数之间的相关性.
- 确定哪些扭曲性特征最能预测促进动脉瘤形成的血液动力学变化.
主要方法:
- 计算流体动力学 (CFD) 模拟在73个具有不同角度和弧度的曲折动脉的理想化模型上进行.
- 血液流动被建模为两个心脏周期的牛顿流体.
- 关键的血液动力学参数,包括时间平均壁切削应力 (TAWSS),TAWSS梯度 (TAWSSG),振荡切削指数 (OSI) 和相对停留时间 (RRT) 在分叉时被计算出来.
主要成果:
- 更多的角度和较长的弧度长度显示出与TAWSS,TAWSSG的正相关性,与RRT的负相关性.
- 平均角度测量与TAWSS,TAWSSG,OSI负相关,与RRT正相关.
- 一个新的扭曲度描述器,通过弧长和分叉距离来规范角度测量,证明了与所有测试的血液动力学参数 (R范围从-0.701到0.778) 存在强烈的相关性.
结论:
- 促进内动脉瘤发展的血液动力学参数与位于较长弧度上的较多小角度有关.
- 与传统的扭曲度指标相比,新开发的扭曲度描述器为评估动脉瘤风险提供了更强大的测量方法.
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