对抗抑郁药的使用和自杀风险的观察性研究被选择性地发表在精神病学期刊上
Martin Plöderl1, Simone Amendola2, Michael Pascal Hengartner2
1Department of Inpatient Psychotherapy and Crisis Intervention, University Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria.
Journal of clinical epidemiology
|August 6, 2023
概括
有有利抗抑郁药物结果的研究更有可能在精神病学期刊上发表,特别是那些有金融利益冲突的作者. 这可能会对抗抑郁药使用和自杀风险的证据基础产生偏见.
科学领域:
- 精神病学是一个精神病学.
- 药学研究 药学研究
- 医学伦理 医学伦理
背景情况:
- 对抗抑郁药物和自杀行为的观察性研究产生了不同的结果.
- 对于报告这些发现的潜在出版偏见和利益冲突存在担忧.
研究的目的:
- 确定是否研究显示有利的抗抑郁药物结果 (降低自杀风险) 首选在精神病学期刊上发表.
- 调查这些有利的研究是否获得了更多的引用,并由金融利益冲突 (fCOI) 的作者进行.
主要方法:
- 对27项原始观察性研究进行了系统审查和二次分析.
- 研究了较新的抗抑郁药物与自杀风险之间的关联.
- 评估出版地点,作者fCOI,期刊影响因子 (IF) 和引用频率.
主要成果:
- 有有利结果的研究更常被发表在精神病学期刊上,无论研究质量如何.
- 有fCOI的主要作者更有可能报告有利的结果.
- 在精神病学期刊中,有利的结果与更高的IF和排名相关,特别是在fCOI的作者身上,尽管调整研究质量后,这一点减弱了.
结论:
- 对抗抑郁药使用和自杀风险的不利发现似乎不太可能在精神病学期刊上发表.
- 患有fCOI的作者往往会在具有影响力的精神病学期刊上发表有利的结果,可能会产生偏见的证据基础.
- 这种选择性传播可能会导致精神病学中对抗抑郁药物的有效性和安全性的不平衡评估.
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