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相关概念视频

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
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As the name suggests, a multiple bar graph is the same as a bar graph but has multiple bars to depict relationships between different data values. One can include as many parameters as possible. However, each parameter must have the same unit of measurement.
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The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
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相关实验视频

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Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development
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HiBrowser:用于同步Hi-C数据可视化的交互式和动态浏览器.

Pingjing Li1,2, Hong Liu3, Jialiang Sun1,2

  • 1College of Computer Science, Nankai University, Tianjin 300071, China.

Briefings in bioinformatics
|August 6, 2023
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概括
此摘要是机器生成的。

HiBrowser是一款用于可视化和分析高通量染色体构成捕获 (Hi-C) 数据的新工具. 它使灵活的多omics导航和同步比较能够更深入地了解基因调节和病理学.

关键词:
这就是Hi-C.标注 标注 标注 标注基因组浏览器 基因组浏览器这是一个同步显示的同步显示.

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 高通量染色体构造捕获 (Hi-C) 对于理解高阶染色体结构和基因调节至关重要.
  • 使用交互式浏览器可视化多omics数据有助于探索疾病中的遗传和表观遗传因素.

研究的目的:

  • 开发HiBrowser,一个有效的浏览器可用于可视化和分析Hi-C数据与相关的遗传和表观遗传注释.
  • 为直观的数据分析提供灵活的多omics导航,多维同步和动态交互.

主要方法:

  • 开发了HiBrowser,这是一个用于可视化Hi-C数据和注释的Web服务.
  • 实现了自定义注释轨道的灵活,按需重建.
  • 引入了一个"克隆模式"用于同步可视化和多个样本的比较 (例如,正常与瘤,泛基因组).
  • 能够精确搜索远端的 cis-regulatory 元素相关性,并在 Hi-C 热图中进行导航.

主要成果:

  • HiBrowser提供灵活的多omics导航和动态交互.
  • "克隆模式"可在多个样本和物种之间进行直观的比较.
  • 支持对cis-regulatory元素的精确搜索和导航.
  • 提供即时的网络服务,并且可以轻松在本地服务器上部署.

结论:

  • HiBrowser是一个有效的,用户友好的工具,用于可视化和分析Hi-C数据和多omics信息.
  • 促进对理解基因调节和疾病机制至关重要的比较分析.
  • 该工具的功能增强了对复杂的基因组相互作用的直观探索.