母乳微生物群的组成会影响婴儿早期微生物群网络结构
Jhen-Wei Ruan1, Yi-Chu Liao2, Pei-Chen Chen1
1Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
概括
母亲的新陈代谢状态影响母乳中的葡萄球菌和链球菌平衡,影响婴儿微生物群的发展. 哺乳婴儿的葡萄球菌占主导地位的牛奶显示了更成熟的肠道和鼻腔微生物组.
科学领域:
- 微生物组研究的研究.
- 婴儿营养 婴儿营养
- 孕产妇健康 孕产妇健康
背景情况:
- 人类母乳 (BM) 对婴儿微生物组发育至关重要.
- 链球菌和葡萄球菌在BM中很常见,但它们对婴儿微生物群成熟的差异性影响尚不清楚.
研究的目的:
- 为了研究母乳中的相对丰富的链球菌和葡萄球菌如何影响婴儿微生物组的成熟.
- 探索母亲的新陈代谢状态和母乳微生物群组成之间的关系.
主要方法:
- 从产后3个月和6个月的母亲收集了母乳样本.
- 在同一时间点收集婴儿鼻腔,口腔和便样本.
- 分析了母乳和婴儿微生物群的组成和共发生网络.
主要成果:
- 母亲的BMI与母乳中的凝血酶阴性葡萄球菌 (CoNS) 丰度相反相关.
- 斯塔菲洛科克卡普雷菌的丰富性与斯特雷波菌的丰富性有负相关性.
- 与那些被养了流性球菌丰富的BM的婴儿相比,被养了Staphylococcus主导的BM的婴儿表现出更发达的肠道和鼻腔微生物群网络.
结论:
- 母亲的新陈代谢状态显著影响母乳中的葡萄球菌/菌菌平衡,影响婴儿微生物群的发展.
- 微生物群共同存在的网络分析可以成为监测婴儿微生物群成熟的宝贵工具.
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