相关实验视频

Updated: Jul 20, 2025

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Published on: April 20, 2021

肌纤维细胞:一种影响子中高脂血症诱导的体洞腔体弹性异常的新因素,通过2D剪切波弹性学检测到

Wan-Ting Rao¹, Shuai Jiang², Yi-Hao Shen¹

¹Department of Medical Ultrasound, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.

Ultrasound in medicine & biology

|August 6, 2023

概括

超脂血症导致子体洞穴体弹性异常. 激活的肌纤维细胞分泌原蛋白,增加组织刚性,通过二维剪切波弹性学 (2-D SWE) 检测到.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
生物医学工程生物医学工程
细胞生物学细胞生物学

背景情况:

二维切割波弹性学 (2-D SWE) 检测高脂血症诱导的洞穴体的弹性变化.
了解这些变化背后的细胞机制对于向治疗至关重要.

研究的目的:

在超脂血性子中研究导致体洞穴弹性异常的细胞学因素.
通过单细胞RNA测序 (scRNA-seq) 来识别特定的细胞类型及其作用.

主要方法:

在新西兰白中,通过高胆固醇饮食诱导高脂血症.
阴茎 2-D SWE 评估了洞体的弹性.
scRNA-seq分析了细胞组成和变化.
免疫组织化学,免疫光学和组织学验证了scRNA-seq发现.

主要成果:

与对照组相比,高脂血症的子显示身体洞穴的Young模量显著增加 (p < 0.001).
组织学发现细胞外基质和原沉积增加 (I型和III型).
scRNA-seq确定了纤维细胞,光滑肌细胞和内皮细胞;在超脂血子中发现了一种新的肌纤维细胞亚型.

结论:

肌纤维细胞在高脂血症中被激活,在体中增殖和分泌多余的原蛋白.
这种原蛋白积累导致异常弹性,由2-D SWE确定.
肌纤维细胞是高脂血症诱导的洞穴体弹性异常的一个关键因素.

关键词:

人体洞穴总和 (Corpus cavernosum) 是一个洞穴总和.超脂血症是因为高脂血症肌纤维母细胞细胞.剪切波弹性图形学剪切波弹性图形学单细胞RNA测序的一个细胞.

更多相关视频

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

相关概念视频

Ultrasound II: Endoscopic Ultrasound and FibroScan

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

Elastin is Responsible for Tissue Elasticity

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...