控制不良的喘 - 简单的胜利和解决真菌过敏的未来前景
David W Denning1, Lorraine T Pfavayi2
1Manchester Fungal Infection Group, The University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.
菌类过敏和暴露会使喘恶化,特别是在资源较低的环境中. 抗真菌疗法在改善喘控制和减少喘恶化方面显示出有前途,为健康提供了显著的益处.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 肺部病理学 肺部病理学
- 菌类学 菌类学是指菌类学.
背景情况:
- 控制不良的喘在全球普遍存在,特别是在资源较低的国家.
- 暴露于真菌和过敏是严重喘的重要因素,导致恶化加剧.
- 性喘包括各种与真菌相关的疾病,包括过敏性支气管肺性阿斯伯吉洛症 (ABPA).
研究的目的:
- 审查真菌过敏和暴露在控制不良的喘中的作用.
- 探索抗真菌治疗和其他治疗真菌喘的疗效.
- 总结有关真菌性喘管理的当前知识和不确定性.
主要方法:
- 对有关真菌性喘,ABPA和相关疾病的现有文献的综述.
- 对抗真菌治疗真菌喘的随机对照研究的分析.
- 讨论环境因素,并发性疾病 (如皮肤菌感染) 和治疗结果.
主要成果:
- 在13项随机对照研究中,抗真菌疗法在9项中显示出好处,减少症状,皮质类固醇需求和恶化,同时改善肺功能.
- 湿建筑物的环境修复改善了喘控制.
- 根除皮肤炎的皮肤感染改善了喘症状.
结论:
- 菌性喘是导致严重和控制不良的喘的一个重要,经常被忽视的因素.
- 抗真菌疗法提供了一个潜在的成本效益和有益的治疗策略,减少对全身皮质类固醇的依赖.
- 需要进一步的研究来解决关于抗真菌疗法的毒性,药物相互作用和耐药性风险的不确定性.
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