eIF3f通过增强结肠直肠癌中除活动来调解SGOC路径重编程
Qihao Pan1,2,3,4, Fenghai Yu2, Huilin Jin2
1Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 6, 2023
概括
细胞启动转化因子3,f亚单元 (eIF3f) 通过通过Wnt和EGF信号调节糖酸脱酶 (PHGDH) 来促进结直肠癌. 针对eIF3f-PHGDH轴提供了新的CRC治疗策略.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 生物化学 生化学
背景情况:
- 蛋白质可以表现出月亮的功能,在它们的主要已知的活动之外发挥作用.
- 在结直肠癌 (CRC) 中,欧核细胞启动转化因子3,f子单元 (eIF3f) 独立于转化所起的具体作用尚不清楚.
研究的目的:
- 调查eIF3f在结直肠癌发展中的非正规功能.
- 阐明eIF3f促进CRC的分子机制,重点关注其与信号通路和关键代谢酶的相互作用.
主要方法:
- 对CRC瘤组织中eIF3f表达的分析.
- 研究Wnt和表皮生长因子 (EGF) 在eIF3f调节和功能中的信号通路的作用.
- 检查eIF3f,糖酸脱酶 (PHGDH) 和无处不在蛋白蛋白酶系统之间的相互作用.
- 评估eIF3f对血清素-甘氨酸-一碳 (SGOC) 代谢途径的影响.
主要成果:
- 在CRC瘤组织中,eIF3f被显著上调.
- 无论是Wnt和EGF信号通路都对eIF3f在CRC中的致癌活性有所贡献.
- eIF3f对抗PHGDH的泛化和降解,增加其稳定性.
- Wnt信号通过转录上调节eIF3f,而EGF信号通过GSK3β抑制PHGDH无处不在.
- 此外,eIF3f还能使MYC脱,进一步增强PHGDH的转录.
- 通过eIF3f提高PHGDH表达增强SGOC通路,促进CRC的进展.
结论:
- eIF3f在促进结直肠癌方面发挥着关键的,非正规的作用.
- 这项研究揭示了一种涉及eIF3f,PHGDH和SGOC在CRC中的信号传输的新机制.
- 针对eIF3f-PHGDH轴是一个有前途的结直肠癌治疗策略.
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