用尼沃卢马布/伊皮利穆马布治疗黑色素瘤的伪进展:一个病例报告
Adan Martin Cuevas Velazquez1, Wern Lynn Ng1, Evelyn J Calderón Martínez1
1Department of Internal Medicine, University of Pittsburgh Medical Center (UPMC) Harrisburg, Harrisburg, PA, USA.
The American journal of case reports
|August 7, 2023
概括
免疫疗法有效地治疗晚期黑色素瘤,使免疫系统能够攻击癌细胞. 仔细评估,包括PET-CT扫描,对于区分真实进展和伪进展至关重要,以确保最佳的患者护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 黑色素瘤是一种侵袭性皮肤癌.
- 免疫疗法,特别是检查点抑制剂,通过向免疫逃避机制,彻底改变了黑色素瘤治疗.
- 黑色素瘤细胞通常具有突变,使它们易受免疫系统攻击.
研究的目的:
- 报告一个以免疫疗法治疗的晚期黑色素瘤病例.
- 为了突出伪进展的现象在免疫治疗的反应.
- 强调对黑色素瘤患者治疗反应的准确评估的重要性.
主要方法:
- 一个74岁妇女患有第四阶段黑色素瘤的病例报告.
- 用尼沃卢马布/伊皮利穆马布治疗,然后用单剂尼沃卢马布治疗.
- 利用计算机断层扫描 (CT) 和正子发射断层扫描-CT (PET-CT) 进行疾病评估.
主要成果:
- 最初的CT扫描显示,在三个循环免疫疗法后,疾病进展.
- 随后的PET-CT扫描显示了完整的代谢反应,表明伪进展.
- 患者耐受良好免疫疗法,并继续在单剂nivolumab.com上表现良好.
结论:
- 伪进展可能发生在黑色素瘤免疫疗法期间,并可能在继续治疗时消失.
- PET-CT成像对于区分伪进展和真正的疾病进展是有价值的.
- 准确评估治疗反应至关重要,以避免在晚期黑色素瘤中提前中止或改变有效免疫治疗.
相关概念视频
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
01:27Tumor Immunotherapy
557
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
557