患有非增殖性狼性炎的患者的长期结局
Eun-Song Kang1, Soo Min Ahn1, Ji Seon Oh2
1Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The Korean journal of internal medicine
|August 7, 2023
概括
非增殖性狼性炎 (LN) 长期影响近30%的患者. 六个月的早期低估计膜过率 (eGFR) 是这些患者脏表现不佳的关键预测因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 非增殖性狼性炎 (LN) (I,II,V类) 通常被认为不那么严重.
- 关于非增殖性LN的长期病预后的数据有限.
研究的目的:
- 调查长期病结果,并确定非增殖性狼性炎患者的预后因素.
主要方法:
- 在1997年至2021年期间诊断的71名全身性红斑狼和非增殖性LN (I,II,V或II+V类) 患者的回顾性审查.
- 糟糕的结结果定义为估计的膜过率 (eGFR) <60毫升/分钟/1.73米2.
主要成果:
- 总的来说,29.6%的患者出现了不良的结局.
- 单变量分析显示,年龄较大,低6个月或12个月的eGFR,在6个月内缺乏完全缓解,以及高的慢性/活动得分与糟糕的结局有关.
- 多变量分析确定6个月低的eGFR作为一个显著的预测因子 (HR 0.971,p=0.014).
结论:
- 大约30%的非增殖性LN患者长期面临不良的结局.
- 对于非扩散性LN,需要提高警,并可能进行更积极的管理.
- 在诊断后6个月,应特别注意EGFR<60mL/min/1.73m2的患者.
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