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Updated: Jul 20, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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使用e-pharmacophore建模和基于大规模虚拟查的结构引导药物发现方法来识别固酶5A的选择性抑制剂

Arooma Maryam1,2,3,4, Abdul Rauf Siddiqi1, Sundeep Chaitanya Vedithi3

  • 1Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, Pakistan.

Journal of biomolecular structure & dynamics
|August 7, 2023
PubMed
概括

研究人员确定了新型选择性酶5A (PDE5A) 抑制剂,对于心血管疾病至关重要. 这些化合物对PDE5A比PDE6A具有很高的特异性,为新的治疗干预提供了潜力.

关键词:
接收人 接收人心血管疾病的心血管疾病.在MM-GBSA中使用.分子动力学模拟模型基于药的虚拟查.选择性的PDE5A抑制剂

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